Medeama Sporting Club handed Hearts of Oak their third defeat in the last three games in the Ghana Premier League.
The game, which was played at the Akoon Park on Wednesday afternoon, saw the Tarkwa-based side record a 2-0 win on matchday 25 of the league.
Kobina Amoah opened the scoring for the Yellow and Mauve side after 65 minutes as he blasted his free-kick into the net to give his side the lead.
Godfred Abban doubled the lead for Medeama with nine minutes away from full time with the midfielder sending his low strike past the Hearts goalkeeper.
The Accra-based side were second favourites in the entire period of the game and failed to recover from the two goals conceded.
The defeat now means the Phobians have lost the last three games they have played in the league after no defeat in the previous eight.
Abubakar Ouattara's men now drop to 11th on the league table after 25 games played and face Karela United in their next game.
In other results, Samartex earned a point with their 1-1 draw with Legon Cities.
Here are the full results from matchday 25:
Medeama SC 2-0 Hearts of Oak
Bibiani Goldstars 3-2 Karela Utd
Berekum Chelsea 3-2 Dreams FC
Heart of Lions 2-0 Accra Lions
Bofoakwa Tano 1-0 Aduana Stars
Real Tamale United 1-0 Nations FC
Legon Cities 1-1 Samartex
Great Olympics 1-1 Bechem United
Credit: Lawrence Degraft Baidoo